A Secret Weapon For ceesdekker
A Secret Weapon For ceesdekker
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Halfway as a result of his occupation, Cees Dekker reinvented himself. After several years of hardcore physics, he shifted his focus to ‘nanobiology’ with the turn on the millennium. A term he coined himself, like a make any difference of truth.
Reconstitution of ultrawide DNA origami pores in liposomes for transmembrane transport of macromolecules
Round the very same time, the group of Paul McEuen, who was then centered for the University of California, Berkeley, confirmed related outcomes on ropes of bundled nanotubes. Depending on the wrapping angle, nanotubes can are available metallic or semiconducting variants, a prediction that we and Charles Lieber’s group at Harvard College independently confirmed using scanning tunnelling spectroscopy experiments.
Deposition and atomic power microscopy of personal phthalocyanine polymers among nanofabricated electrodes
2010, designed a different way (‘wedging transfer’) to govern nanostructures; first report of DNA translocation by means of graphene nanopores; and understood hybrid nanopores by directed insertion of α-hemolysin into good-point out nanopores
Cornelis (Cees) Dekker (Haren, seven april 1959) is een Nederlandse natuurkundige en universiteitshoogleraar verbonden aan de Technische Universiteit Delft. Van 2010 tot en satisfied 2018 was hij tevens directeur van het Kavli Institute of Nanoscience in Delft. Zijn vakgebied is de moleculaire biofysica; hierbij beweegt hij zich op het grensvlak van de natuurkunde en de biologie waarbij hij gebruikmaakt van de zogeheten nanotechnologie, de technieken om aan enkele atomen en moleculen te kunnen meten.
We use nanofabricated microfluidic buildings to sample spatial boundaries for micro organism and biomimetic vesicles with reconstituted protein networks which assess the fundamental function of spatial confinement on the molecular and cellular level. Our projects include the subsequent:
Dynamic ParB–DNA interactions initiate and manage a partition condensate for bacterial chromosome segregation
In 1993, for a youthful and eager associate professor at Delft College of Technology, I had originally focused the analysis initiatives of my team on measuring the electrical conductance of a single conducting-polymer molecule. In two decades, we had produced a device where only one wire of a phthalocyaninepolysiloxane polymer was connected among two carefully spaced metallic nanoelectrodes.
Resolving the move sizing in condensin-pushed DNA loop extrusion identifies ATP binding given that the move-building system
Because 2000 he moved to one-molecule biophysics and nanobiology, with investigation from research of DNA loop extrusion and supercoiling to DNA translocation as a result of nanopores. Far more lately his investigate has focused on researching chromatin construction and cell division with micro organism on chip, whilst he is usually trying to finally Construct artificial cells from the bottom up.
Cees Dekker is Distinguished University Professor at TU Delft. Qualified for a physicist, he pioneered nanotechnology with numerous discoveries on carbon nanotubes inside the nineties. Given that 2000, he moved to single-molecule biophysics and nanobiology. His present study focuses on (i) nanopores for protein sequencing; (ii) chromosome framework, especially SMC motor protein; and (iii) developing a residing synthetic cell from lifeless molecules. Dekker is an elected member of your KNAW and fellow into the APS along with the IOP.
2008, 1st observation of protein-coated DNA translocation by nanopores; solved the origin on the electrophoretic pressure on DNA in nanopores; uncovered a major velocity enhance of microtubules in electrical fields; learned an anomalous electro-hydrodynamic orientation of microtubules; and solved the origin of sound in carbon nanotubes in liquid
Instance (two) of bending configurations ceesdekker in 3D simulations of DNA rods on nanopores. A part of the membrane is revealed in grey, the rim with the pore is highlighted in crimson, in addition to a 3D rendering in the movement on the DNA rod is displayed.